Lines and Research Projects for the Postgraduate Program in Dental Sciences

Buco maxillofacial Surgical Therapy

Project 1: In vitro and in vivo studies on the biological effects of biomaterials, drugs and therapeutic interventions

Description: Development of preclinical studies employing cell culture or animal experimentation methods, the effects of biomaterials, devices, substances and interventions used for tissue regeneration and improvement of the tissue repair process.

Head of Project: Maria Cristina Zindel Deboni (teacher)

Project 2: Evaluation of the Effects of Therapeutic Procedures in the Pre, Trans and Postoperative Buco maxillofacial Surgeries

Description: Development of clinical trials to study the therapeutic effects of medications and interventions in the pre and postoperative moments of oral and maxillofacial surgery and in the treatment of facial fractures.

Head of Project: Maria da Graça Naclério-Homem (teacher)

Project 3: Diagnosis, Case Study, Planning and Treatment of Dental Injuries and Facial Injuries

Description: Development of retrospective and prospective clinical studies on epidemiological, clinical demographic aspects, diagnostic procedures and treatment of diseases and injuries of odontogenic origin and facial trauma. To study innovative methodologies for diagnostic and surgical imaging planning and to evaluate the outcomes of surgical therapies used in the treatment of dental and maxillofacial disorders.

Head of Project: João Gualberto de Cerqueira Luz (teacher)

Project 4: Bone Regeneration Therapies

Description: Research line that investigates therapeutic strategies for the treatment of bone defects, aiming at tissue regeneration. The studies are developed with a translational approach and are related to the following themes: stem cell culture, osteoblasts and osteoclasts, biomaterials, growth factors, bone tissue engineering and cell therapy, using in vitro and in vivo experimental models.

Head of Project: Emanuela Prado Ferraz (teacher)

Anthropology, skills and bioethics

The objective of this line of research is to evaluate techniques for conducting expertise in different fields of dental practice (civil, criminal, administrative / ethical and labor), taking into account bioethical aspects of dental education.

This research line refers to the Forensic Dentistry and Collective Health area and has the following projects:

Project 1: Physical Anthropology and Anatomical Aspects of the Brazilian Population

Description: The objective of this project is to study peculiar characteristics of the Brazilian population and to compare them with other populations, regarding their potential for human identification with forensic purpose.

Head of project: Edgard Michel Crosato (teacher)

Project 2: Forensic Facial Recognition and Reconstruction

Description: Forensic facial reconstruction is a technique used for the purpose of recognition and subsequent identification, in situations where there is no identity attributable to the skeleton submitted to forensic examination. Facial recognition techniques for official records also offer invaluable value. The objective of this project is to allow the development of parameters and equipment for facial recognition and reconstruction, allowing the Court to assist in cases where there is such a need.

Head of Project: Rodolfo Francisco Haltenhoff Melani (teacher)

Project 3: Age Estimation for Forensic Purpose

Description: Estimating an individual’s age can play an important role in human identification processes. The objective of this project is to test techniques for making estimates in Brazilian adults and children, allowing the Court to assist in cases where there is such a need.

Head of Project: Maria Gabriela Haye Biazevic (teacher)

Project 4: Valuation of Personal Injury and its Expert Implications

Description: Injury may be civil, criminal, labor and administrative in nature, and in cases of civil nature compensation is measured by the extent of the damage and, therefore, clinically evaluable damage parameters as well as aesthetic heritage should be appropriately valued for full compensation of bodily harm. Regardless of the nature of the damage, there is still a lack of standardization of concepts, methods and language in the Brazilian experts, and the development of protocols is fundamental for establishing more equitable compensation. The objective of this project is to develop and validate methods and instruments of analysis of body damage in order to bring greater objectivity to the expertise and scientific basis for the conduct.

Head of Project: Rogério Nogueira de Oliveira (teacher)

Public policy, education and epidemiology

Public health policies and evolution of oral health conditions of the population, through epidemiological studies in oral health and quality of life analysis. Human resources training in dentistry.

This research line refers to the Forensic Dentistry and Collective Health area and has the following projects:

Project 1: Epidemiology, Quality of Life and Social Inequalities in Oral Health

Description: Study of the oral health problems of people in the community, aiming to analyze its occurrence, spatial distribution, impact on quality of life and its relationship with socioeconomic conditions.

Head of Project: Edgard Michel Crosato (teacher)

Project 2: Dental Education and Health Training

Description: New technologies have been used for the development of teaching-learning strategies in various areas of knowledge. In dentistry, curricular and operational changes have made it possible to adapt to the new demands of the contemporary world. The objective of the project is to study strategies that enable greater use in teaching-learning activities. The training of human resources in dentistry and the constant monitoring of the evolution of their professional activities are also analyzed in this project, by analyzing the professional activity profile of dental surgeons and auxiliary professions in both the public and private sectors, in their involvement in individual and collective activities, and in the management of human, financial, quality and evaluation of public and private dental service establishments.

Head of Project: Maria Ercilia de Araujo (teacher)

Project 3: Public Policy and Collective Oral Health

Description: The execution of collective outreach projects is the objective of this Project, which aims to serve populations with diverse oral health care needs, as well as to evaluate the performance of these actions in improving community health conditions and formulating public policies of health.

Head of Project: Fernanda Campos de Almeida Carrer (teacher) (docente)

Oral health promotion in children and adolescents

The objective of this line of research is to study the main oral diseases in deciduous and permanent dentition in the epidemiological, educational, clinical and laboratory contexts seeking to promote the oral health of children and adolescents.

This research line refers to the area of ​​Pediatric Dentistry and Orthodontics and has the following projects:

Project 1: Impact of Oral Health Disorders on Deciduous and Permanent Dentition and Quality of Life

Description: The objective of this project is to investigate epidemiological aspects of oral diseases, such as dental caries, traumatic injuries, malocclusions and other injuries related to the hard tissues of the teeth, as well as the impact and repercussion of these diseases on the health and quality of life children and adolescents.

Head of Project: Marcelo José Strazzeri Bönecker (teacher)

Project 2: Diagnosis and Treatment Decision of Oral Health Disorders

Description: Oral health problems in children and adolescents are known to be important to be diagnosed, so that the best treatment approach can be proposed. Although this diagnostic step seems obvious, it involves a complex hypothetical-deductive process that will guide the best treatment decision focused on the condition in question. Given this scenario, the objective of the project will be to investigate, in both epidemiological and clinical contexts, different methods and systems for detection and evaluation of common diseases in childhood and adolescence, such as dental caries, dental trauma, dental erosion and malocclusions, as well as to construct the best available evidence for the best treatment decisions to solve such problems in both studied contexts.

Head of Project: Fausto Medeiros Mendes (teacher)

Project 3: Public Policies for Integral Child Development, Health Training, Interprofessional Education, Development of New Approaches and Educational Resources, Technology-Mediated Education and Health Care, and Digital Health.

Description: The objective of this project is to explore and evaluate new possibilities in the construction of educational content and approaches, including technology-mediated learning, applied to health education, which is directed to children, their families and the community, and also applied to health education, which is directed to dentists and other health professionals. It also aims to develop studies related to education and work in health, with emphasis on interprofessional education, as well as education and health care mediated by technology and involving emerging themes in digital health. The themes under study are considered in their interface with the formulation, management and evaluation of public policies.

Head of Project: Ana Estela Haddad (teacher)

Project 4: Clinical and Laboratory Tests of Dental Materials Used in Pediatric Dentistry

Description: This project aims to evaluate through randomized clinical trials or laboratory tests the behavior of different restorative and dental materials used in Pediatric Dentistry, with the aim of trying to predict their long-term clinical behavior. Systematic reviews are also carried out on the topics studied, leading to a greater understanding of existing scientific evidence and guiding the possibility and need for future work.

Head of Project: Daniela Procida Raggio (teacher)

Project 5: Patients with Special Needs – Study of General Systemic Conditions and Possible Oral Health Related Disorders

Description: This project aims to evaluate a possible association between the various general pathologies observed in children and adolescents and oral health problems, establishing appropriate treatment proposals for this population.

Head of Project: Ana Lídia Ciamponi (teacher)

Project 6: Impact and different approaches to oral disease treatment – clinical and teaching implications

Description: This project aims to explore the impact of some treatments commonly employed in Pediatric Dentistry, both in terms of their effect (effectiveness / effectiveness), as well as focusing on their economic impact and patient-centered outcomes. It is also a current proposal to create subsidies to contribute with the construction of the best scientific evidence on the topic, but also with ways of dissemination to undergraduates and professionals about the clinical application of such concepts.

Head of Project: Mariana Minatel Braga (teacher)

Project 7: Dental trauma and its repercussions for teething

Description: In this project are the works that address dental trauma in deciduous and permanent teeth and their repercussions for dentitions; including education, prevention, epidemiology, diagnosis, treatment and repercussions.

Head of Project: Marcia Turolla Wanderley (teacher)

Application of methods of diagnosis orthodontic treatment

This research aims to evaluate through biomechanical tests and clinical studies the performance and mechanical behavior of devices used in the manufacture of orthodontic and orthopedic appliances. It is also important to evaluate the diagnostic methods that can be employed to make a better treatment decision, as well as to evaluate the dento-skeletal changes that may occur after orthodontic treatment using various resources and methodologies.

This research line refers to the area of Pediatric Dentistry and Orthodontics and has the following projects:

Project 1: Diagnosis and Biomechanics Used in the Treatment of Dentofacial Deformities

Description: This project aims to analyze the results of biomechanics used in tooth and skeletal movement in the treatment of dentofacial imbalances, associated with surgical procedures or not, with fixed or removable appliances.

Heado of Project: José Rino Neto (teacher)

Project 2: Laboratory Study to Evaluate Orthodontic Movement Biomechanics Using Different Types of Accessories

Description: This project aims to analyze through biomechanical tests, using in vitro or animal material, the biomechanical performance of different types of orthodontic wires, fixtures or devices employed in the correction of dentofacial imbalances, using fixed or removable appliances.

Heado of Project: João Batista de Paiva (teacher)

Project 3: Efficiency and / or Effectiveness Assessment of Different Methods Applied in Orthodontic Treatments

Description: This project aims to evaluate, through clinical or animal studies, the efficacy, efficiency and changes in facial symptomatology, teeth position support tissues when photomodulation and or pain-related markers are used and osteoclastogenesis.

Head of Project: Gladys Cristina Domiguez-Morea (teacher)

Epidemiology, etiopathogenesis, diagnosis and treatment of complex maxillofacial diseases

This line aims to study the molecular, cellular and morphological aspects of diseases that affect the mandibular maxillary complex, as well as deepen the knowledge of medical topics related to dentistry, especially assessing the impact of conditions and oral diseases on the overall health of the individual and vice-versa.

This line of research refers to the area of Oral and Maxillofacial Pathology and Special Patients and has the following projects:

Project 1: Morphofunctional Study and Biomarkers of Oral and Maxillofacial Lesions

Description: This research project aims to study the histopathological and molecular aspects of various lesions that affect the oral and maxillofacial region, from various sources within the tissues that comprise this region, namely, epithelial neoplasms, salivary gland neoplasms, neoplasms odontogenic, potentially malignant lesions, reactive lesions, among others, seeking to know the mechanisms of disease development with a view to improving diagnosis and treatment. For this purpose, techniques of histochemistry, immunohistochemistry and molecular biology are used.

Head of project: Suzana Cantanhede Orsini Machado de Sousa (teacher)

Project 2: Impact of congenital and acquired systemic diseases on oral health

Description: The main objective of this research project is to deepen the knowledge of medical issues in relation to diseases or systemic conditions that have an impact on oral health or dental treatment of patients, as well as to recognize the impact of oral conditions on the overall health of the individual. The research developed aims to reach points such as epidemiology, etiopathogenesis, diagnosis and treatment of oral manifestations of acquired chronic systemic diseases, develop forms of dental management (outpatient and hospital) of patients with peculiar medical conditions such as diabetes, kidney failure, organ transplantation, radiotherapy treatment and identify the oral-facial alterations present in patients with congenital diseases. The main feature of this project is to use evidence-based dentistry to conduct translational studies, which accelerate the bi-directional exchange between basic and clinical science for applied environments involving patients and populations.

Head of Project: Marina Helena Cury Gallottini (teacher)

Project 3: Repair mechanisms in inflammatory and neoplastic lesions

Description: The objective of this project is to critically and deeply address the main repair mechanisms in inflammatory and neoplastic lesions, with emphasis on the oral mucosa and gnathic bones. This project includes research aimed at studying the molecular events of inflammatory and neoplastic processes directly linked to repair mechanisms, including signaling pathways that refer to tumor resistance. The project is characterized by including methodologies for experimental laboratory and clinical analysis, involving situations in which there is impairment of the process of repair of oral tissues, whether derived from local or systemic factors. The studies are directed to the analysis of the inflammatory and reparative phenomenon itself in face of these factors, as well as to the investigation of the efficacy / efficiencies of new therapies, including biomaterials, stem cells and phototherapy.

Head of Project: Luciana Corrêa (teacher)

Project 4: Study of Molecular and Cellular Mechanisms of Carcinogenesis

Description: The objective of this project is to study the cellular and molecular mechanisms involved with carcinogenesis, maintenance and progression of malignant and benign tumors of the buco maxillofacial region. Therefore, different methodologies are used to study these mechanisms, including in vitro techniques, mainly with cell lines, and in vivo, in animal model. Biological materials from patients (fresh or paraffin tissue, blood and saliva) are frequently used, mainly because this project also aims to find molecular markers for diagnosis, treatment response prediction, survival, as well as molecules that can serve as therapeutic target.

Head of Project: Fabio Daumas Nunes (teacher)

Project 5: Immunohistochemical and molecular biomarkers in maxillofacial complex lesions

Description: This research project aims to study biomarkers (protein, genetic, epigenetic, microbiological and inflammatory) in pathological conditions of the maxillofacial complex, seeking the existence of potential diagnostic and prognostic markers. The aim is to establish an expression profile of these markers and their possible association with clinical, imaging and histopathological characteristics presented by these lesions. The main pathological entities studied in the project are: odontogenic tumors, inflammatory periapical lesions, pulpitis, leukoplakia, oral and oropharyngeal squamous cell carcinomas, periodontal disease in systemically compromised patients and radiotherapy and chemotherapy-induced mucositis in cancer patients.

Head of Project: Paulo Henrique Braz da Silva (teacher)

Project 6: Clinical-pathological studies of reparative processes and diseases of the oral and maxillofacial complex

Description: The broad area of ​​oral and maxillofacial complex pathologies is addressed by this project, which includes morphological and molecular studies in neoplasm, potentially malignant disorders, reactive and cystic lesions of various origins that affect the region. The main objective is to unravel the mechanisms of disease repair and development, relating clinical data to cellular and molecular aspects. Another aspect of this project aims to evaluate cancer stem cells, both in the initiation and progression of cancer and in resistance to treatments currently employed in oncology. The methodologies used are multiple, involving cell biology, molecular techniques and animal models.

Head of Project: Marilia Trierveiler Martins (teacher)

Project 7: Evaluation of jaw disorders using cone beam computed tomography

Description: Cone-Beam Computed Tomography (CBCT) is a method that has shown better results than conventional radiography in the diagnosis of jaw disorders. This project aims to study the accuracy and accuracy of CBCT for several maxillofacial complex lesions. For this, numerous image acquisition and postprocessing protocols will be studied in order to determine which is the best image diagnosis system for the lesions.

Head of Project: Marcelo de Gusmão Paraíso Cavalcanti (teacher)

Project 8: Oral manifestations and treatment of patients with systemic diseases

Description: The main objective of this research project is to deepen the knowledge of oral manifestations and dental treatment of patients with some systemic diseases. The research developed aims to reach points such as epidemiology, etiopathogenesis, diagnosis and treatment of oral manifestations of chronic systemic acquired diseases, develop forms of dental management (outpatient and hospital) of patients with medical conditions such as liver disease, coagulation disorders, HIV infection and by HTLV.

Head of Project: Karem López Ortega (teacher)

Project 9: Carcinogenesis

Description: The objective of this project is to study the cellular mechanisms involved with carcinogenesis, especially regarding the main signaling pathways. Therefore, different methodologies are used to study these mechanisms, with special emphasis on in vitro techniques, especially with cell lines. Within this concept, different drugs with potential action of suppression of proliferation leading the neoplastic cell to apoptosis are studied.

Head of Project: Décio dos Santos Pinto Júnior (teacher)

Etiopathogenesis, diagnosis and therapy of periodontal diseases

This research aims to evaluate the effectiveness of various periodontal therapeutic modalities and the association of clinical, immunological and microbiological parameters with the etiology, pathogenesis and diagnosis of periodontal diseases, as well as their association with systemic health.

This line of research refers to the area of Periodontics and has the following projects:

Project 1: Etiopathogenesis of Periodontal Disease

Description: There is considerable evidence that periodontal diseases are initiated by microorganisms that colonize teeth and adjacent periodontal tissues. However, periodontal destruction results from the host’s immune-inflammatory response to the presence of periodontopathogens. The aim of this project is to evaluate the microbiological factors and immunological mechanisms associated with periodontal destruction, as well as to elucidate the role of host response determining and modifying factors (systemic and environmental factors) in the periodontal inflammatory process.

Head of Project: Marinella Holzhausen Caldeira (teacher)

Project 2: Risk Factors of Periodontal Disease

Description: The association between systemic and periodontal diseases has been investigated for decades. However, other systemic factors have recently emerged as possible risk factors for periodontal disease. Moreover, there is a lack of information in the literature regarding the effect of controlling certain risk factors, such as smoking, on response to periodontal treatment. Therefore, this project will aim to investigate the association of systemic habits and conditions with periodontal disease, as well as the effect of periodontal treatment in patients with systemic diseases, and the effect of control of systemic factors on periodontal condition. The effect of treatment of diabetes, smoking cessation, and treatment of kidney and liver transplant patients on periodontal parameters will be evaluated.

Head of Project: Cláudio Mendes Pannuti (teacher)

Project 3: Reconstructive Therapy in Implantology

Description: Bone resorption of the alveolar process may limit implant placement and impact patient aesthetics and quality of life. Thus, the present project will investigate techniques and biomaterials for the preservation of the alveolar process, as well as the effect of reconstructive therapies on the edge area, aiming at implant placement.

Head of Project: Giuseppe Alexandre Romito (teacher)

Project 4: Advanced Therapies in Periodontics

Description: Tissue engineering and cell-based therapies have emerged as new therapeutic approaches for more predictably promoting regeneration and expanding the therapeutic boundaries of regenerative therapy for a wide variety of defects. This project investigates the biological behavior and regenerative potential of mesenchymal cells, aiming to design future advanced therapeutic alternatives in the resolution of periodontal disease and in the regeneration of periodontal defects.

Head of Project: Cristina Cunha Villar (teacher)

Project 5: Reconstructive Surgical Therapy in Periodontics

Description: Reconstructive periodontal therapies are used to promote the recovery of tissues lost due to disease progression or trauma. One of the objectives of this project is to evaluate the effect of surgical techniques for gingival enlargement in regions with gingival retraction and small band of keratinized tissue. In addition, this project investigates the effect of therapies for bone regeneration and periodontal ligament.

Head of Project: João Batista César Neto (teacher)

Project 6: New Strategies for the Control of Diseases Associated with Oral Biofilm

Description: This proposal aims to establish foundations for the development of new strategies for the control of periodontitis and other oral diseases associated with biofilm. The hypothesis to be tested is that the balance in the oral microbiota-immune response relationship, lost in periodontitis, could be recovered by favoring colonization of the oral cavity by beneficial bacteria and by modulating the immune response. It will also be tested the hypothesis that probiotic microorganisms or their products are capable of controlling diseases associated with biofilm, by presenting antagonistic relationship to pathogenic microbiota, and can be used as adjuvants to conventional treatment.

Head of Project: Marcia Pinto Alves Mayer (teacher)

Project 7: Treatment and rehabilitation in patients with aggressive periodontitis

Description: Aggressive periodontitis is a disease that leads to great bone and insertion loss. Its etiology is complex and there are still big questions to be answered regarding the etiology, microbiology, immune response, treatment modalities, prognosis and maintenance of these cases. The present project aims to evaluate the treatment and rehabilitation of these patients, as well as follow them longitudinally, assessing tooth loss and changes in periodontal parameters.

Head of Project: Luciana Saraiva (teacher)

Oral rehabilitation, maxillofacial and osseointegrated implants

This research line refers to the area of ​​Rehabilitation in Dentistry and has the following projects:

Project 1: Drug Therapy in Dentistry

Description: The objective of this project is to evaluate the effect of various anesthetic, analgesic, anti inflammatory and antimicrobial drugs on dental therapy. The action of controlled drug delivery systems, for example antimicrobial and anti-inflammatory drugs applied to various dental specialties will also be verified.

Head of Project: Isabel de Freitas Peixoto (teacher)

Project 2: Integrated Dentistry Treatment

Description: The objective of this research project is to evaluate the effect of therapeutic methods in various dental specialties, aiming at the integrated treatment of the patient, as well as the treatment of dental emergencies. Methods will be studied for the treatment of alveolitis and pulpitis, among other urgencies. Rehabilitation techniques with prostheses and implants will also be studied; the effect of the addition of nanoparticles to the surface of implants and other biomaterials and the behavior of polymers as release devices of various therapeutic drug forms.

Head o Project: Rodney Garcia Rocha (teacher)

Project 3: Performance Evaluation of Extraoral, Dental and Prosthetic Components Implants

Description: Analyze qualitatively, through computer simulations, finite element analysis, biomechanical assays of the various implant types, the force distributions on them and their various implant supported bucomaxilofacial systems in addition to its various geometries, prosthetic materials and implants, to evaluate the biomechanical behavior of intra and extraoral implants in the rehabilitation of large orofacial losses.

Head of Project: Reinaldo Brito e Dias (teacher)

Project 4: Sport Dentistry and Orofacial Trauma Prevention

Description: To study the oral health of athletes, their systemic and physiological interactions, risks, preservation and preservation of the ideal physical condition. To study the mechanical behavior of facial trauma, the possible means of protection and the materials used in the manufacture of orofacial protectors.

Head of Project: Neide Pena Coto (teacher)

Project 5: Orofacial Prosthetic Rehabilitation and Health Conditions in Patients with Developmental or Acquired Anomalies

Description: This project studies the prevalence, diagnosis and treatment of certain orofacial conditions in individuals who require special care such as those undergoing head and neck radiotherapy, patients with cleft lip and / or palate, fracture of the face and teeth, as well as as buco maxillofacial prosthetic rehabilitation.

Head of Project: Beatriz Silva Câmara Matos (teacher)

Project 6: Clinical Procedures and Behavior of Implant-Related Prosthetic Restorative Materials, Implant Supported Prostheses and Dental Prosthetics

Description: This project aims to study the new technologies and restorative materials employed in osseointegrated prostheses and implants, as well as to evaluate their scope in the aesthetic and functional rehabilitation of the stomatognathic system, in the clinical and laboratory context.

Head of Project: Newton Sesma (teacher)

Project 7: Evaluation of the stomatognathic system structures regarding the behavior of the temporomandibular joints, through instituted therapies and the influence on the postural balance of the individual, when the presence of implants, considering the applicability of the CAD / CAM system.

Description: The project aims to investigate the behavior and applicability of devices that can detect and / or restore signs and symptoms of the temporomandibular joints and their relationship with balance, employing different types of materials in individuals with or without integrated bone implants. These are designed and implemented under CAD / CAM technology. Also the project aims to evaluate the quality of its implantation according to the treatment of its surface and osseointegration level and the integrity of the peri implant tissues.

Head of Project: Dalva Cruz Laganá (teacher)

Project 8: Digital Technologies Applied to Dental Prosthesis and Implantology

Description: The objective of this project is to analyze the accuracy of materials and techniques applied to the CAD – CAM system, as well as their use in the areas of Dental and Implant Dentistry.

Head of Project: Pedro Tortamano Neto (teacher)




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